Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis.
Identifieur interne : 009955 ( Main/Exploration ); précédent : 009954; suivant : 009956Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis.
Auteurs : C L King [États-Unis] ; M. Connelly ; M P Alpers ; M. Bockarie ; J W KazuraSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2001.
Descripteurs français
- KwdFr :
- 12-Myristate-13-acétate de phorbol (pharmacologie), Activation des lymphocytes (), Adolescent, Adulte, Adulte d'âge moyen, Animaux, Cytokines (antagonistes et inhibiteurs), Cytokines (biosynthèse), Enfant, Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (transmission), Filariose lymphatique (épidémiologie), Humains, Indice de gravité médicale, Interleukine-4 (sang), Ionomycine (pharmacologie), Lymphocytes T (immunologie), Lymphocytes T (métabolisme), Lymphocytes auxiliaires Th2 (immunologie), Lymphocytes auxiliaires Th2 (métabolisme), Mâle, Papouasie - Nouvelle-Guinée (épidémiologie), Phytohémagglutinine (pharmacologie), Tolérance immunitaire (), Wuchereria bancrofti (immunologie).
- MESH :
- antagonistes et inhibiteurs : Cytokines.
- biosynthèse : Cytokines.
- immunologie : Filariose lymphatique, Lymphocytes T, Lymphocytes auxiliaires Th2, Wuchereria bancrofti.
- métabolisme : Lymphocytes T, Lymphocytes auxiliaires Th2.
- parasitologie : Filariose lymphatique.
- pharmacologie : 12-Myristate-13-acétate de phorbol, Ionomycine, Phytohémagglutinine.
- sang : Interleukine-4.
- épidémiologie : Filariose lymphatique, Papouasie - Nouvelle-Guinée.
- Activation des lymphocytes, Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Femelle, Humains, Indice de gravité médicale, Mâle, Tolérance immunitaire.
- Wicri :
- geographic : Papouasie-Nouvelle-Guinée.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Child, Cytokines (antagonists & inhibitors), Cytokines (biosynthesis), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (transmission), Female, Humans, Immune Tolerance (drug effects), Interleukin-4 (blood), Ionomycin (pharmacology), Lymphocyte Activation (drug effects), Male, Middle Aged, Papua New Guinea (epidemiology), Phytohemagglutinins (pharmacology), Severity of Illness Index, T-Lymphocytes (immunology), T-Lymphocytes (metabolism), Tetradecanoylphorbol Acetate (pharmacology), Th2 Cells (immunology), Th2 Cells (metabolism), Wuchereria bancrofti (immunology).
- MESH :
- chemical , antagonists & inhibitors : Cytokines.
- chemical , biosynthesis : Cytokines.
- chemical , blood : Interleukin-4.
- geographic , epidemiology : Papua New Guinea.
- drug effects : Immune Tolerance, Lymphocyte Activation.
- epidemiology : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, T-Lymphocytes, Th2 Cells, Wuchereria bancrofti.
- metabolism : T-Lymphocytes, Th2 Cells.
- parasitology : Elephantiasis, Filarial.
- chemical , pharmacology : Ionomycin, Phytohemagglutinins, Tetradecanoylphorbol Acetate.
- transmission : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Child, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Humans living in areas where filariasis is endemic vary greatly in their exposure to mosquito-borne infective third-stage larvae (L3) of these parasitic helminths. Because the intensity of exposure to Ags affects T cell differentiation and susceptibility to parasitic infections in murine models, we compared T cell and cytokine responses in 97 residents of two villages in Papua New Guinea, where transmission intensity of Wuchereria bancrofti differed by 63-fold (37 vs 2355 L3 per person per year). Residents of the high transmission village had 4- to 11-fold lower proliferation and IFN-gamma responses to filarial Ags, nonparasite Ag, and PHA by PBMC compared with the low transmission village (p < 0.01) even when subjects were matched for intensity of infection. In contrast, filarial Ag-driven IL-5 production was 5.5-fold greater (p < 0.001), and plasma IL-4 and TGF-beta levels were 4-fold and 34% higher, respectively, in residents of the high transmission village. IL-4 and IL-10 responses by PBMC differed little according to village, and increased production of the counterregulatory cytokines IL-10 or TGF-beta by PBMC did not correlate with weak proliferation and IFN-gamma responses. Plasma IL-5, IFN-gamma, and IL-10 levels were similar in the two villages. These data demonstrate that the intensity of exposure to L3 affects lymphocyte responsiveness and cytokine bias possibly by a mechanism that alters APC function.
PubMed: 11390495
Affiliations:
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Bockarie</name></author><author><name sortKey="Kazura, J W" sort="Kazura, J W" uniqKey="Kazura J" first="J W" last="Kazura">J W Kazura</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11390495</idno><idno type="pmid">11390495</idno><idno type="wicri:Area/PubMed/Corpus">004806</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004806</idno><idno type="wicri:Area/PubMed/Curation">004806</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004806</idno><idno type="wicri:Area/PubMed/Checkpoint">004806</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004806</idno><idno type="wicri:Area/Ncbi/Merge">000671</idno><idno type="wicri:Area/Ncbi/Curation">000671</idno><idno type="wicri:Area/Ncbi/Checkpoint">000671</idno><idno type="wicri:doubleKey">0022-1767:2001:King C:transmission:intensity:determines</idno><idno type="wicri:Area/Main/Merge">009D53</idno><idno type="wicri:Area/Main/Curation">009955</idno><idno type="wicri:Area/Main/Exploration">009955</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis.</title><author><name sortKey="King, C L" sort="King, C L" uniqKey="King C" first="C L" last="King">C L King</name><affiliation wicri:level="2"><nlm:affiliation>Division of Geographic Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. cxk21@po.cwru.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Geographic Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Connelly, M" sort="Connelly, M" uniqKey="Connelly M" first="M" last="Connelly">M. 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Bockarie</name></author><author><name sortKey="Kazura, J W" sort="Kazura, J W" uniqKey="Kazura J" first="J W" last="Kazura">J W Kazura</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Cytokines (antagonists & inhibitors)</term><term>Cytokines (biosynthesis)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Elephantiasis, Filarial (transmission)</term><term>Female</term><term>Humans</term><term>Immune Tolerance (drug effects)</term><term>Interleukin-4 (blood)</term><term>Ionomycin (pharmacology)</term><term>Lymphocyte Activation (drug effects)</term><term>Male</term><term>Middle Aged</term><term>Papua New Guinea (epidemiology)</term><term>Phytohemagglutinins (pharmacology)</term><term>Severity of Illness Index</term><term>T-Lymphocytes (immunology)</term><term>T-Lymphocytes (metabolism)</term><term>Tetradecanoylphorbol Acetate (pharmacology)</term><term>Th2 Cells (immunology)</term><term>Th2 Cells (metabolism)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>12-Myristate-13-acétate de phorbol (pharmacologie)</term><term>Activation des lymphocytes ()</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Cytokines (antagonistes et inhibiteurs)</term><term>Cytokines (biosynthèse)</term><term>Enfant</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (transmission)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Indice de gravité médicale</term><term>Interleukine-4 (sang)</term><term>Ionomycine (pharmacologie)</term><term>Lymphocytes T (immunologie)</term><term>Lymphocytes T (métabolisme)</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Lymphocytes auxiliaires Th2 (métabolisme)</term><term>Mâle</term><term>Papouasie - Nouvelle-Guinée (épidémiologie)</term><term>Phytohémagglutinine (pharmacologie)</term><term>Tolérance immunitaire ()</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Interleukin-4</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Papua New Guinea</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immune Tolerance</term><term>Lymphocyte Activation</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Lymphocytes T</term><term>Lymphocytes auxiliaires Th2</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>T-Lymphocytes</term><term>Th2 Cells</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>T-Lymphocytes</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes T</term><term>Lymphocytes auxiliaires Th2</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>12-Myristate-13-acétate de phorbol</term><term>Ionomycine</term><term>Phytohémagglutinine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ionomycin</term><term>Phytohemagglutinins</term><term>Tetradecanoylphorbol Acetate</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Interleukine-4</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Papouasie - Nouvelle-Guinée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Mâle</term><term>Tolérance immunitaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Papouasie-Nouvelle-Guinée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Humans living in areas where filariasis is endemic vary greatly in their exposure to mosquito-borne infective third-stage larvae (L3) of these parasitic helminths. Because the intensity of exposure to Ags affects T cell differentiation and susceptibility to parasitic infections in murine models, we compared T cell and cytokine responses in 97 residents of two villages in Papua New Guinea, where transmission intensity of Wuchereria bancrofti differed by 63-fold (37 vs 2355 L3 per person per year). Residents of the high transmission village had 4- to 11-fold lower proliferation and IFN-gamma responses to filarial Ags, nonparasite Ag, and PHA by PBMC compared with the low transmission village (p < 0.01) even when subjects were matched for intensity of infection. In contrast, filarial Ag-driven IL-5 production was 5.5-fold greater (p < 0.001), and plasma IL-4 and TGF-beta levels were 4-fold and 34% higher, respectively, in residents of the high transmission village. IL-4 and IL-10 responses by PBMC differed little according to village, and increased production of the counterregulatory cytokines IL-10 or TGF-beta by PBMC did not correlate with weak proliferation and IFN-gamma responses. Plasma IL-5, IFN-gamma, and IL-10 levels were similar in the two villages. These data demonstrate that the intensity of exposure to L3 affects lymphocyte responsiveness and cytokine bias possibly by a mechanism that alters APC function.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><noCountry><name sortKey="Alpers, M P" sort="Alpers, M P" uniqKey="Alpers M" first="M P" last="Alpers">M P Alpers</name><name sortKey="Bockarie, M" sort="Bockarie, M" uniqKey="Bockarie M" first="M" last="Bockarie">M. Bockarie</name><name sortKey="Connelly, M" sort="Connelly, M" uniqKey="Connelly M" first="M" last="Connelly">M. Connelly</name><name sortKey="Kazura, J W" sort="Kazura, J W" uniqKey="Kazura J" first="J W" last="Kazura">J W Kazura</name></noCountry><country name="États-Unis"><region name="Ohio"><name sortKey="King, C L" sort="King, C L" uniqKey="King C" first="C L" last="King">C L King</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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